Purpose: The precise mechanisms of tumorigenesis of breast cancer remains unknown in spite of major efforts. Recent studies have shown that High Mobility Group Ⅰ (Y) Proteins [HMGI(Y)] have an important role in the regulation of chromatin
structure and function, and that HMGI(Y) protein expression is generally correlated with a malignant phenotype. This study was undertaken to define the relationship of the HMGI(Y) protein expression between malignant breast tissue and
non-malignant
breast tissue in human, and clinicopathologic findings were reviewed for this purpose.
Methods: Using Reverse Transcription-Polymerase Chain Reaction (RT-PCR) for HMGI(Y) with β-actin, this study demonstrated the expression of HMGI(Y). The p53, ER, and PR. were defined by immunohistochemical staining.
Results: The HMGI(Y) expression was increased in the malignant tissue (90%), than in benign (76.9%) or normal (65%) tissue (p=0.031). As for the invasive ductal cancers, there was no difference between the HMGI(Y) expression and
histopathologic
parameters.
Conclusion: These results suggest that the HMGI(Y) expression may be of little pathogenetic prognostic importance in human breast cancer.
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